低频rTMS对创伤性颅脑损伤患者颅内压影响的实验研究

目的探讨低频重复经颅磁刺激(rTMS)对创伤性颅脑损伤(TBI)患者颅内压(ICP)的影响。方法32例急性中重型TBI患者分为非手术组及手术组,再分别将其随机分为常规治疗组(A组)及低频rTMS治疗组(B组)。采用无创颅内压检测分析仪测定患者的IcP。结果非手术组中B组患者的IcP均低于A组(P0.05);手术组中,B组患者的IcP在第1天与A组相比差异无统计学意义(p0.05),但有下降趋势,在第3天、第7天、第9天均低于A组(P0.05)。结论低频rTMS可以降低TBI后患者的ICP,从而起到脑保护作用。

Experimental study on effect of low-frequency repetitive transcranial magnetic stimulation on intracranial pressure among traumatic brain injury patients

Objective To investigate the effect of low-frequency repetitive transcranial magnetic stimulation （rTMS） on intracranial pressure （ICP） among traumatic brain injury （TBI） patients. Methods Thirty-two patients with acute moderate or severe TBI were divided into non-surgical group and surgical group. Each group was further divided randomly into conventional treatment group （subgroup A） and low-frequency rTMS treatment group （ subgroup B）. ICP values were measured by a noninvasive intracranial pressure monitor. Results In the non-surgical group, the ICP values of patients in subgroup B were significantly lower than those in subgroup A （P 〈 0.05 ）. In the surgical group, the ICP values of patients in subgroup B showed a decreasing trend on the first day, but were not significantly different from those in subgroup A （P 〉0.05）. ICP values of patients in group B were all lower than those in subgroup A on the 3rd, 7th, and 9th days （P 〈 0.05）. Conclusions Low-frequency rTMS may protect the brain of patients with TBI through reducing ICP.