先天性梅毒感染性死胎1例尸检的病理观察

目的 探讨先天性梅毒感染性胎儿的病理特点。方法 ①尸体解剖观察大体形态；②显微镜观察主要脏器组织学改变。结果 本例病理特点主要为：①胎盘苍白肿大；②多脏器纤维化伴不同程度梅毒螺旋体浸润；③梅毒感染性肝硬化、胰腺炎和关节骨软骨炎等。结论 患梅毒孕妇的梅毒螺旋体通过胎盘进入胎儿血液，并播散至肝、脾、肾上腺、心、肺等脏器中大量增殖，导致胎儿感染并胎死宫内。

Pathological features of infectious stillborn infant by syphilis: an autopsy report and review of literatures

Objective To study the pathological features of fetal death infected with congenital syphilis (CS).Methods The gross morphology was observed by autopsy and histological changes of major organs by microscope.Results The main histological characteristics of the congenital syphilis were placental enlargement,multiple organ fibrosis and syphilitic cirrhosis,syphilitic pancreatitis and syphilitic osteochondritis in this case.Conclusion Spirochaeta pallidum in the syphilitic mother enters the fetal blood through placenta,disseminates to multiple organs and proliferates there,and results in fetal death in uterus ultimately.