原发性肝癌术中化疗泵埋置途径选择的研究

目的　探讨原发性肝癌 (PHC)病灶在不同切除方式时化疗泵埋 (DDS)置途径的选择。方法　将 190例原发性肝癌患者按手术切除方式分为原发肿瘤完整切除 (A)、未完全切除 (B)组两组。再根据肿瘤不同切除方式时所采用置泵途径 ,两大组各分为经肝动脉 门静脉双途径置泵 (a)组、经门静脉 (b)组、经肝固有动脉 (c)三组。结果　 (1)A组中 ,c组的 1年、3年复发率均高于b组 ;a组的 1年、3年复发率与b组无差异。b组与a、c两组相比 ,其生存率与a组无明显差异 ,较c组生存率高。 (2 )B组中 ,a组的 1年、3年生存率与b组有显著差别 ;c组预后差于a组 ,但与b组无差别。结论　在原发肿瘤完整切除的情况下 ,首选经门静脉置泵 ;在原发肿瘤未能完整切除的患者 ,只能选择双途径置泵。

Researches on implantation methods for the drug deliver system during the operation for primary liver carcinoma

Objective To study the optimal method for drug delivery system (DDS) in plantation primary liver carcinoma. Methods All the cases (190) were divided into two groups with tumor resection completely (A) or not (B). Each group has three subgroups (a, b, c) respectively according to the pathway to implant drug delivery system. Results (1) The 1, 3 year's recurrence rate of subgroup c in group A was higher than in subgroup b, but there was no significant difference b. The 1, 3 year's survival rate of b was similar to that of subgroup a and superior to that of group c. (2) There was significant difference in the 1, 3 year's survival rate between group a and group b in group B. The prognosis of group c was inferior to group a and there was no significant difference when compared group b. Conclusions The drug delivery system should be implant into the portal vein when the tumor was removed completely and it may be better to implant the drug delivery system into both portal vein and hepatic artery if the tumor can't be resected completely.