中西医结合治疗原发性难治性肾病综合征的meta分析

目的:系统评价中西医结合治疗难治性肾病综合征(Refractory Nephritic Syndrome,RNS)的疗效,为中西医结合治RNS提供科学依据。方法:用循证医学的方法,选用国内外多个权威数据库为资料源,对国内近10年间(2001～2010)正式发表的临床研究文献进行手工检索。按照国际cochrane协作网的系统评价方法,对所纳入的研究进行方法学质量评价,并选取11篇质量良好的随机对照试验(RCT)运用Rev.Man5.0.23软件进行Meta分析。结果:共检索到11个符合纳入标准的RCT,共计922例患者,其中中西医结合组478例,对照组444例。Meta分析显示,在治疗后中西医结合组与对照组的总有效率差异有统计学意义RR=4.04,95%CI(2.85,5.70),合并效益Z=7.93(P<0.00001)]。结论:中西医结合治疗RNS有助于提高其临床疗效,减少激素或免疫抑制剂不良反应的发生。

Meta-Analysis of combined Chinese and Western Medicine in Primary Refractory Nephritic Syndrome

Objective: To evaluate the therapeutic effect of the Chinese and Western Medicine combination in Refractory Nephritic Syndrome(RNS),for providing a scientific basis in combined Chinese and Western Medicine in RNS.Methods: To search the clinical research literature which officially published nearly ten years(2001~2010) in a number of domestic and international authoritative database,By using the evidence-based medicine method.Then take methodological quality assessment for the included studies in accordance with international Cochrane network system assessment method.Meta-analysis was Performed using Rev.Man5.0.23 software for 11 best quality randomized controlled trials(RCT).Results: Searching 11 the standard RCTs,a total of 922 patients,including 478 cases of combination of traditional Chinese and Western medicine group,444 cases in the control group.Meta analysis showed that,after treatment with integrated traditional Chinese and Western medicine group and control group in the total efficiency difference has statistics significance RR=4.04,95%CI(2.85,5.70),the combined benefit of Z=7.93(P<0.00001)].Conclusion: It is contributes to improve clinical efficacy,take reduction of corticosteroid or immunosuppressive adverse reaction for combined Chinese medicine with western medicine in treatment of RNS.