The Effects of Hypothyroidism on 5-HT1A and 5-HT2A Receptors and the Serotonin Transporter Protein in the Rat Brain |
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Authors: | Kulikov A V Jeanningro R |
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Institution: | (1) Siberian Division, Russian Academy of Sciences, Institute of Cytology and Genetics, 10 Lavrent'ev Prospekt, 630090 Novosibirsk, Russia;(2) INSERM U38, Fonction Thyroidienne et Regulations, Marseilles, France |
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Abstract: | The effects of hypothyroidism on 5-HT1A and 5-HT2A receptors and the serotonin transporter protein were studied in thyroidectomized male Wistar rats in two experimental groups: 1) animals kept on an iodine-free diet (hypothyroid rats) and 2) animals kept on thyroxine (15 g/kg) for 21 days (giving normal thyroid hormone levels, euthyroid animals). Sham-operated rats served as controls. Binding of 3H]8-OH-DPAT with 5-HT1A receptors and 3H]citalopram with the transporter protein in the hippocampus and midbrain showed no changes in hypothyroid rats as compared with controls. Conversely, there were significant decreases in 3H]ketanserin binding to 5-HT2A receptors in the frontal cortex in hypothyroid rats as compared with controls; this decrease was reversed by thyroxine treatment. Thus, losses of cortical 5-HT2A receptors appears to be the main consequence of hypothyroidism at the level of the serotonin system of the brain. |
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Keywords: | 5-HT1A receptors 5-HT2A receptors serotonin transporter hypothyroidism thyroxine brain |
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