针刺对功能性便秘ENS-ICC调节机制的研究进展

功能性便秘(functional constipation,FC)是临床常见病和多发病,其病因和发病机制尚不十分清楚,存在多种学说.实验研究表明,"泻药性结肠"动物模型结肠表现为肠神经系统神经丛超微结构、多种受体与ICC表达的异常.我们通过检索和分析近年来针刺治疗FC的实验研究文献,发现目前针刺对FC的调节机制的研究偏于单一化,多种机制之间的调控关系没有进行深入研究.今后的研究应侧重针刺对各机制之间相互关系的阐释以及对其关键机制的探讨,使针刺作用机制的研究进一步深入,从而更好地服务于临床.

Progress in understanding mechanisms underlying the regulatory effect of acupuncture on functional constipation

Functional constipation is a common and frequently-occurring disease whose etiology and pathogenesis are still not very clear.Experimental studies using animal models of cathartic colon have shown abnormalities in ultrastructural plexus of enteric nervous system(ENS),expression of multiple receptors,and interstitial cells of Cajal(ICC).Currently,there has been no consensus reached yet with regard to the mechanisms underlying the regulatory effect of acupuncture therapy on functional constipation,and the interaction among different regulatory mechanisms is not examined in depth.Future research should address this issue to better understand how acupuncture exerts therapeutic effects against functional constipation.