The clinical status of cadaveric renal transplant patients treated for 10 year with cyclosporine therapy |
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Authors: | Claudio Ponticelli Adriana Aroldi Attilio Elli Giuseppe Montagnino Antonio Vegeto Antonio Tarantino |
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Affiliation: | Divisione di Nefrologia e Dialisi, IRCCS, Ospedale Maggiore, Milan, Italy. croff1@polic.cilea.it |
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Abstract: | In this paper we assessed the clinical status of 150 cadaveric renal transplant patients who received cyclosporine without interruption for 10 yr. The mean creatinine clearance was 59.2 +/- 15.71 at 1 yr and 55.6 +/- 24.91 mL/min at 10 yr (p = 0.039). Patients were subdivided into four quartiles according to the mean creatinine clearance at 1 yr. The 14 patients with the lowest quartile showed a significant decrease of creatinine clearance from the 1st to 10th year (from 31.5 +/- 5.83 to 24.8 +/- 14.00 mL/min; p = 0.038) while no difference between the mean creatinine clearance at 1 and at 10 yr was found in the other three quartiles. At 10 yr, 84.6% patients needed antihypertensive therapy, a rate similar to that seen at 1 yr (81.4%). The mean plasma cholesterol (253 +/- 57.8 mg/dL) and triglyceride (197 +/- 113.1 mg/dL) at 10 yr were similar to those found at +/- yr (243 +/- 48.2 and 201 +/- 143.0 mg/dL, respectively). Most patients have a high degree of rehabilitation 10 yr after uninterrupted cyclosporine therapy and all patients but 3 were able to work. |
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Keywords: | chronic rejection cyclosporine nephrotoxicity renal transplantation |
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