| 瑞香狼毒醇提物体外抗肿瘤作用研究 |
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| 引用本文： | 刘晓霓,李玉洁,杨庆,刘安,朱晓新. 瑞香狼毒醇提物体外抗肿瘤作用研究[J]. 中国中药杂志, 2010, 35(22): 3048-3051 |
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| 作者姓名： | 刘晓霓 李玉洁 杨庆 刘安 朱晓新 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 中国博士后基金项目(20090450550);中国中医科学院基本科研业务自选课题项目(Z02065) |
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| 摘 要： | 目的:体外观察瑞香狼毒醇提物AESC,AESC-1,AESC-2的抗肿瘤作用。方法:采用MTT和SRB法观察AESC,AESC-1,AESC-2对5种肿瘤细胞(A549,NCI-H157,NCI-H460 3种肺癌细胞株,BEL-7402,SK-HEP-1 2种肝癌细胞株)的抑制率,计算IC50,GI50,TGI和LC50。结果:AESC,AESC-1,AESC-2对各细胞株均具有抑制作用,并具有一定的时间依赖性。作用72 h,100,200 mg.L-1各受试药对各细胞株(除A549外)的抑制率在64.82%~92.27%。AESC和AESC-2对NCI-H460和BEL-7402细胞株的IC5020 mg.L-1,AESC-1对SK-HEP-1细胞株IC5020 mg.L-1。AESC,AESC-1,AESC-2对敏感细胞株的平均GI5040 mg.L-1,平均TGI90 mg.L-1,平均LC50150 mg.L-1。AESC和AESC-2对敏感细胞株的平均GI50,TGI和LC50值相似。结论:AESC,AESC-1,AESC-2均具有明显抗肿瘤作用,且对不同细胞株敏感性不同;AESC-2与AESC抗肿瘤作用方式相似,AESC的抗肿瘤活性部位可能主要存在于AESC-2。
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| 关 键 词： | 瑞香狼毒 抗肿瘤 |
| 收稿时间： | 2010-01-12 |
Anti-tumor effect of alcohol extract of Stellera chamaejasme in vitro |
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| LIU Xiaoni,LI Yujie,YANG Qing,LIU An and ZHU Xiaoxin. Anti-tumor effect of alcohol extract of Stellera chamaejasme in vitro[J]. China Journal of Chinese Materia Medica, 2010, 35(22): 3048-3051 |
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| Authors: | LIU Xiaoni LI Yujie YANG Qing LIU An ZHU Xiaoxin |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | Stellera chamaejasme anti-tumor |
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