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| 低分子量肝素诱导重症急性胰腺炎大鼠胰腺腺泡细胞凋亡的实验研究 | |
| 引用本文： | 范钦桥,陈书伟,杨根辉,刘博,曹文声,于毅,吕新生,范立侨. 低分子量肝素诱导重症急性胰腺炎大鼠胰腺腺泡细胞凋亡的实验研究[J]. 中国医师杂志, 2009, 11(3): 342-344 |
| 作者姓名： | 范钦桥 陈书伟 杨根辉 刘博 曹文声 于毅 吕新生 范立侨 |
| 作者单位： | 1. 湖南省郴州市第一人民医院肝胆外科,湖南,郴州,423001 2. 中南大学湘雅医院普通外科 3. 河北医科大学第四医院外三科 |
| 摘 要： | 目的探讨低分子肝素（LMWH）治疗重症急性胰腺炎的机理。方法建立假手术组（S组）、重症急性胰腺炎组（SAP组）和LMWH治疗组（H组），比较各组死亡率、血清淀粉酶、IL-6、腺泡细胞凋亡指数和胰腺组织NF-κB活性。结果H组死亡率、血清淀粉酶和IL-6明显低于SAP组（P〈0．01）。H组腺泡细胞凋亡指数明显高于SAP组（P〈0．01）。H组胰腺组织NF-κB活性明显低于SAP组。结论LMWH可能通过抑制NF-κB的活性，从而诱导了胰腺腺泡细胞凋亡，减轻胰腺炎症程度。 |
| 关 键 词： | 肝素 低分子量/药理学 胰腺炎/病理生理学 胰腺/细胞学 细胞凋亡 |
Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis |
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| FAN Qin-qiao,CHEN Shu-wei,YANG Gen-hui,LIU Bo,CAO Wen-sheng,YU Yi,LU Xin-sheng,FAN Li-qiao. Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis[J]. Journal of Chinese Physician, 2009, 11(3): 342-344 | |
| Authors: | FAN Qin-qiao CHEN Shu-wei YANG Gen-hui LIU Bo CAO Wen-sheng YU Yi LU Xin-sheng FAN Li-qiao |
| Affiliation: | FAN Qin-qiao, CHEN Shu-wei, YANG Gen-hui,LIU Bo, CAO Wen-sheng, YU Yi,LU Xin-sheng, FAN Li-qiao(Department of Hepatobiliary Surgery ,The First People＇s Hospital of Chengzhou City,Chengzhou 423001 ,China) |
| Abstract: | Objective To explore the mechanism of LMWH therapy for SAP.Methods 48 wistar rats were random divided into 3 groups,sham group(S group),severe acute pancreatitis group(SAP group)and LMWH therapy group(H group).Serum amylase,IL-6,acinar cell apoptosis and the activity of NF-κB were detected and compared.Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group(P＜0.01).The apoptosis index of acinar cell in SAP group wag significantly lower than that in H group(P＜0.01),while the activity of NF-κB in SAP groupwas stronger than that in H group.Conclusions LMWH therapy may ameliorate SAP by inducing acinar cell apoptosis through suppressing the activity of NF-κB. |
| Keywords: | Heparin,low-molecule-weight/PD Pancreatitis/PP Pancreas/CY Apoptosis |
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