55例急性白血病患者血小板参数的研究

目的：研究急性白血病患者血小板计数（ Ｐ Ｌ Ｔ） 、血小板压积（ Ｐ Ｃ Ｔ） 、平均血小板体积（ Ｍ Ｐ Ｖ） 及血小板体积分布宽度（ Ｐ Ｄ Ｗ） 的临床意义。方法：用血细胞分析仪测定５５ 例初诊急性白血病（ Ａ Ｌ） ，化疗后骨髓抑制、完全缓解（ Ｃ Ｒ） 患者及２７ 例正常人的血小板参数 Ｐ Ｌ Ｔ、 Ｐ Ｃ Ｔ、 Ｍ Ｐ Ｖ 及 Ｐ Ｄ Ｗ。结果：初诊组 Ｐ Ｌ Ｔ、 Ｐ Ｃ Ｔ、 Ｍ Ｐ Ｖ 明显低于对照组及完全缓解组（ 均为 Ｐ＜ ０ ．０１ ， Ｐ＜ ０ ．０１ ， Ｐ＜ ０ ．０５） ，但显著高于骨髓抑制组（ Ｐ＜ ０ ．０５ ， Ｐ＜ ０ ．０１ ． Ｐ＜ ０ ．０１） ，初诊组 Ｐ Ｄ Ｗ 亦显著高于骨髓抑制组，但与其他各组无显著差异（ Ｐ＞ ０ ．０５） 。 Ｃ Ｒ 组血小板四项参数与对照组比亦无明显差异（ Ｐ＞ ０ ．０５） 。结论：血小板四项参数的测定有利于预示病程及血小板功能。

STUDY ON PLATELET PARAMETERS IN 55 CASES OF ACUTE LEUKEMIA

Objective:To investigate the clinical implication of the platelet counts (PLT),platelet crit (PCT),mean platelet volume (MPV) and platelet volume distribution width (PDW)in the acute leukemias.Method:Using automated blood cell analyzer to determine the platelet parameters of PLT\,PCT\,MPV and PDW in 55 cases of the onset of acute leukemias,the bone marrow suppression post-chemotherapy and complete remission (CR) patients and 27 cases of normal human beings.Results:PLT\,PCT\,MPV in the group of onset was significantly lower than that of the control group and the CR group (both P<0.01,P<0.01,P<0.05 respectively),but significantly higher when it was compaired with the bone marrow suppression group(P<0.05,P<0.01,P<0.01 respectively).PDW in the onset group was also higher than that of the bone marrow suppression group significantly,but was not significantly different from the other groups (P>0.05).Four platelet parameters in the CR group showed no significantly difference from the contrast group (P>0.05).Conclusion:The determination of the four platelet parameters are usefull to evaluate the prognosis of the disease and it's platelet functions.