急性胰腺炎患者血清sE-selectin和sICAM-1水平的变化及其意义

目的 探讨急性胰腺炎(acute pancreatitis,AP)患者外周血清可溶性E-选择素(sE-selectin)和可溶性细胞间黏附分子-1(sICAM-1)水平的变化及其临床意义.方法 41例AP患者根据中国AP诊治指南中的临床诊断及轻症胰腺炎和重症胰腺炎分类标准分为2组:重症胰腺炎组 19例和轻症胰腺炎组 22例.2组患者于入院第1、3、 7、14 天时采集血清,采用ELISA法检测血清sE-selectin和sICAM-1水平.另取20例健康体检者作对照.结果 重症胰腺炎组第1、3、 7天血清sE-selectin和sICAM-1水平均明显高于轻症胰腺炎组和对照组(P均<0.05),重症胰腺炎组第14天血清sE-selectin和sICAM-1水平与对照比较差异均无统计学意义(P均>0.05);轻症胰腺炎组第1、3天血清sE-selectin和sICAM-1水平均明显高于对照组(P均<0.05),轻症胰腺炎组第7天血清sE-selectin和sICAM-1水平与对照组比较差异均无统计学意义(P均>0.05).结论 血清sE-selectin和sICAM-1水平与AP病情的发展有一定的关系,对评价AP的严重程度、AP的病程判断和疗效可能具有重要意义.

The Changes of sE-selectin and sICAM-1 Level in the Periphery Serums of Acute Pancreatitis Patients and Its Clinical Significances

Objective To explore the changes of sE-selectin and sICAM-1 levels in the periphery serums of acute pancreatitis patients and its clinical significances.Methods 41 patients of acute pancreatitis were divided into severe acute panereatitis(SAP,19 cases)group and mild acute pancreatitis(MAP,22 cases)group.Serums of these cases were collected on the 1,3,7 and 14 day(SAP)after admission,then using ELISA to determine sICAM-1 and sE-selectin level in serum.The other 20 healthy volunteers were taken as contrasts.Results Obviously,the serum sE-selectin and sICAM-1 levels of SAP were higher than those of MAP group and normal contrast on the 1,3,7 day(all P<0.05),but there was no statistic significance between the serum sE-selectin and sICAM-1 levels on the 14 day(all P>0.05).The serum sE-selectin and sICAM-1 levels of MAP group were markedly higher than those of normal contrast on the 1,3 day(all P<0.05),but there were no statistic significance between the serum sE-selectin and sICAM-1 levels on the 7 day(all P>0.05).Conclusion The levels of sE-selectin and sICAM-1 in serums are relatively correlated with the clinical progression of AP and they probably are importantly significant in judging the severity,prognosis of AP and curative effects.