| 胰岛素对猪主动脉平滑肌细胞的增殖和前列环素合成的影响 |
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| 引用本文： | 刘江华 刘宗汉. 胰岛素对猪主动脉平滑肌细胞的增殖和前列环素合成的影响[J]. 中国糖尿病杂志, 1995, 3(3): 148-151 |
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| 作者姓名： | 刘江华 刘宗汉 |
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| 作者单位： | 湖南衡阳医学院附属第一医院内分泌科，湖南衡阳医学院内分泌研究室，上海第二医科大学瑞金医院血液分子生物学中心室 |
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| 摘 要： | 以体外培养的猪主动脉平滑肌细胞为实验模型，研究了不同浓度胰岛素对其细胞增殖、前列环素合成的影响。结果显示胰岛素抑制平滑肌细胞的前列环素合成、促进细胞增殖都呈现剂量依赖性，提示高胰岛素血症可能是致动脉粥样样硬化的重要因素之一。
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| 关 键 词： | 胰岛素 平滑肌细胞 高胰岛素血症 动脉粥样硬化 |
The effects of insulin on the production of prostacyclin and cell proliferation in cultured porcine aortic smooth muscle cells |
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| Liu Jiang-hua,Liu Zong-han, Chen Cuo-qiang,et al. The effects of insulin on the production of prostacyclin and cell proliferation in cultured porcine aortic smooth muscle cells[J]. Chinese Journal of Diabetes, 1995, 3(3): 148-151 |
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| Authors: | Liu Jiang-hua Liu Zong-han Chen Cuo-qiang et al |
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| Abstract: | The effects of insulin on the synthesis of prostacyclin(PGI2) and cell proliferation in cultured porcine aortic smooth muscle cells(SMC) were studied. The results showed that insulin reduced production of PGI2 and stimulated cell proliferation in SMC, which were dose-dependent.These suggested that hyperinsulinemia might be one of the important factors in causing atherosclerosis. |
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| Keywords: | Insulin Aortic smooth muscle cells Prostacyclin |
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