Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation |
| |
Authors: | Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil |
| |
Affiliation: | Ihab I El Hajj, Shahid M Malik, Hany R Alwakeel, Obaid S Shaikh, Hossam M Kandil, Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, PA 15213, United StatesEizaburo Sasatomi, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States |
| |
Abstract: | Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile.However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury. |
| |
Keywords: | Celecoxib Cholestatic hepatitis Liver failure Liver transplantation |
本文献已被 维普 万方数据 等数据库收录! |
| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 |
|