Fulminant liver failure in a child with invasive group A streptococcal infection |
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Authors: | Biesel-Desthieux M-N Tissières P Belli D C Le Coultre C Gervaix A Masserey Spicher V |
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Institution: | Department of Pediatrics and Pediatric Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland. |
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Abstract: | Liver involvement is mentioned in streptococcal toxic shock syndrome, but never as fulminant liver failure (FLF). We report the case of a 2-year-old child who developed isolated FLF secondary to invasive group A streptococcal infection without shock due to a M1T1-type strain expressing speA, speB and speC toxin genes. On antibiotics, he recovered rapidly without liver transplantation. CONCLUSION: A streptococcal pyrogenic exotoxin likely constituted the initial insult leading to FLF. This etiology can be included in the differential diagnosis of FLF and would support early introduction of antibiotics. |
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