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Fulminant liver failure in a child with invasive group A streptococcal infection
Authors:Biesel-Desthieux M-N  Tissières P  Belli D C  Le Coultre C  Gervaix A  Masserey Spicher V
Institution:Department of Pediatrics and Pediatric Surgery, University Hospital of Geneva, 1211 Geneva 14, Switzerland.
Abstract:Liver involvement is mentioned in streptococcal toxic shock syndrome, but never as fulminant liver failure (FLF). We report the case of a 2-year-old child who developed isolated FLF secondary to invasive group A streptococcal infection without shock due to a M1T1-type strain expressing speA, speB and speC toxin genes. On antibiotics, he recovered rapidly without liver transplantation. CONCLUSION: A streptococcal pyrogenic exotoxin likely constituted the initial insult leading to FLF. This etiology can be included in the differential diagnosis of FLF and would support early introduction of antibiotics.
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