Migration patterns of donor astrocytes after reciprocal striatum-cerebellum transplantation into newborn hosts. |
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Authors: | C Jacque I Suard P Collins N Baumann |
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Institution: | Laboratoire INSERM U-134, H?pital de la Salpêtrière, Paris, France. |
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Abstract: | Fragments of striatum or cerebellum from E 25 rabbit embryo were implanted into either the striatum or the mesencephalon of newborn mice. Implanted rabbit astrocytes were selectively identified by monoclonal antibodies to the GFAP which are unable to combine with mouse GFAP. Previous investigations had shown that xenogenic astrocytes have the capacity to migrate in host CNS. The purpose of this study was to compare the patterns of migration of transplant-derived astroglial cells according to the topographic origin of the transplant and location of the grafting site. We found that the migration pattern of the grafted cells from any of both selected sites of implantation was independent from the topographic origin of the transplant. The routes as well as the distances of migration were similar after homo- or heterotopic transplantation. We conclude that astroglial cells or their precursors do not express information which would direct them to move specifically toward a defined region in the host brain according to the region of origin in the donor. |
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Keywords: | transplantation astrocytes topographic specificity migration glial fibrillary acidic protein mouse xenograft |
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