Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair |
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| Authors: | Chao‐Chun Yang Hamm‐Ming Sheu Pei‐Lun Chung Chung‐Hsing Chang Yau‐Sheng Tsai Michael W Hughes Tai‐Lan Tuan Lynn L H Huang |
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| Institution: | 1. Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan;2. Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;3. International Research Center of Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan;4. Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan;5. The Saban Research Institute of Children's Hospital Los Angeles and Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;6. Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan;7. Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan, Taiwan;8. Research Center of Excellence in Regenerative Medicine, National Cheng Kung University, Tainan, Taiwan |
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| Abstract: | Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair cycle, the lowest in early anagen phase, upregulated in late anagen phase and the highest in the telogen phase. On the other hand, leptin receptor is detected in keratin 15‐positive hair bulge epithelium of both anagen‐ and telogen‐phase hair follicles of mice pelage and vibrissa hair, and hair from human scalp. Leptin contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair as demonstrated in organ culture and coculture system. Our data suggest that leptin of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium. |
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| Keywords: | adipocytes adipokines hair follicles leptin |
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