| 急性肝损伤动物模型的建立 |
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| 引用本文： | 田洪,潘善庆,陈子渊.急性肝损伤动物模型的建立[J].中国药师,2009,12(4):449-450. |
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| 作者姓名： | 田洪 潘善庆 陈子渊 |
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| 作者单位： | 湖南省药品检验所,长沙,410001 |
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| 摘 要： | 目的：以对乙酰氨基酚、四氯化碳、氨基半乳糖为肝毒剂，建立急性肝损伤动物模型。方法：分别测定不同剂量对乙酰氨基酚、四氯化碳、氨基半乳糖所致急性肝损伤模型小鼠血清丙氨酸氨基转移酶（ALT）水丰。结果：剂量为100mg·kg^-1的对乙酰氨基酚、浓度为0．05％～1．0％四氯化碳及剂量600，800mg·kg^-1的氨基半乳糖造模后均能明显升高小鼠血清ALT水平。结论：对乙酰氨基酚、四氯化碳、氨基半乳糖造模可用于保肝药的筛选与评价。
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| 关 键 词： | 急性肝损伤 动物模型 对乙酰氨基酚 四氯化碳 氨基半乳糖 |
Establishment of the Animal Models of Acute Hepatic Injury |
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| Tian Hong,Pan Shanqing,Chen Ziyuan.Establishment of the Animal Models of Acute Hepatic Injury[J].China Pharmacist,2009,12(4):449-450. |
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| Authors: | Tian Hong Pan Shanqing Chen Ziyuan |
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| Institution: | ( Hunan Institute of Drug Control, Changsha 410001, China) |
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| Abstract: | Objective： To extablish the animal models of acute hepatic injury induced by acetaminophen, arbon tetrachloride and D-galactosamine. Method： The serum ALT level in those mice were determined. Result： The ALT level was significantly increased by ip acetaminophen 100mg· kg^- 1, ig 0.05 % - 1.0% carbon tetrachloride and ip D-galactosamine 600,800mg· kg ^- 1 respectively. Conclusion： The models made by these three drugs can be used for screening and evaluation of new drugs. |
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| Keywords: | Acute hepatic injury Animal model Acetaminophen Carbon tetrachloride D-galactosamine |
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