Cys-c和NAG联合检测在糖尿病肾病早期的诊断意义

目的探讨半胱氨酸C（Cys-c）与N-乙酰-β-D-氨基葡萄糖苷酶（NAG）联合检测对糖尿病肾病早期的诊断意义。方法检测62例糖尿病患者（其中空腹血糖大于7.8mmol/L的患者35例作为血糖控制欠佳组,空腹血糖小于或等于7.8mmol/L的患者27例作为血糖控制良好组）的Cys-c、肌酐（Cr）、尿素氮（BUN）和NAG指标,同时随机选择65名健康体检者为对照组。结果糖尿病患者的血清中Cys-c和尿液中NAG与对照组比较均明显上升,差异有统计学意义（P〈0.01）;血糖控制良好组患者的Cys-c和NAG明显低于血糖控制欠佳组,差异有统计学意义（P〈0.01）。结论 Cys-c和NAG联合检测对糖尿病肾病早期有重要的诊断价值。

The significance of detection on cysteine C and NAG in diagnosis of early diabetic nephropathy

Objective To explore the significance of detecting cysteine C（Cys-c） and N-acetyl-β-D-glucosaminidase（NAG）in diagnosis of early diabetic nephropathy.Methods The Cys-c,Cr,BUN and NAG indexes of 62 cases of diabetes（including 35 cases of fasting blood glucose 7.8 mmol/L patients as poorly controlled glycaemic group,and 27 cases of fasting blood glucose≤7.8 mmol/L patients as well controlled glycemic group） were detected.Meanwhile 65 healthy people were selected randomly as the control group.Results The Cys-c and NAG of diabetic group were significantly increased compared with the control group（P〈0.01）.The Cys-c and NAG in the well-controlled group were significantly lower than those in the poorly controlled group（P〈0.01）.Conclusion The combined detection of Cys-c and NAG in patients with early diabetic nephropathy has important diagnostic value.