拉米夫定联合中药对乙型肝炎患者表面抗原定量的影响

目的观察拉米夫定联合自拟小柴胡加减汤对肝郁脾虚型慢性乙型肝炎患者乙型肝炎病毒表面抗原(HBsAg)定量及乙型肝炎病毒(HBV)DNA载量的影响。方法将74例慢性乙型肝炎患者分为对照组34例,治疗组40例,治疗组给予拉米夫定联合中药汤剂治疗、对照组给予拉米夫定治疗,治疗6个月,观察患者HBsAg定量、HBV DNA载量的变化。结果 (1)治疗6个月后,两组HBsAg定量比较,差异无统计学意义(P>0.05);治疗组与对照组HBsAg定量治疗后差值比较,差异无统计学意义(P>0.05)。(2)治疗3个月后,两组HBV DNA定量分级情况、HBV DNA定量阳性结果、两组治疗前后HBV DNA阳性结果对比,差异均无统计学意义(P>0.05)。治疗6个月后,两组HBV DNA定量分级情况对比,差异有统计学意义(P<0.05)。治疗组与对照组HBV DNA阳性结果对比,差异有统计学意义(P<0.05)。对照组治疗后与治疗前HBV DNA阳性结果对比,差异无统计学意义(P>0.05)。治疗组治疗后与治疗前HBV DNA阳性结果对比,差异有统计学意义(P<0.05)。结论小柴胡加减汤联合拉米夫定可抑制乙型肝炎病毒复制。

Effect of Lamivudine in combination with Chinese medicine on quantitative detection of hepatitis B surface antigen in patients with chronic hepatitis B

Objective To evaluate the effect of Lamivudine combined xiaochahujiajiantang on HBsAg antigen in patients with chronic hepatitis B.Methods 74 chronic hepatitis B patients were randomly divided into 2 groups,40 in the control group,and 34 in the treated group.The treated group was treated with Lamivudine in Combination with xiaochahujiajiantang for 6 months,the control group was treated with Lamivudine for 6 months.At the 3th,6th month during the treatment,HBV DNA and HBsAg antigen were observed.at 6th month.Results（1）After treatment of 6 months,there was no significant difference of HBsAg antigen in two groups（P0.05）.（2）After 3 months of treatment,there were no significant difference of HBV DNA quantitative classification,HBV DNA quantitative positive results and HBV DNA positive results HBsAg of two groups before and after treatment（P0.05）.After 6 months of treatment,there was significant difference of HBV DNA quantitative classification between two groups（P0.05）,there was significant difference of HBV DNA positive results in two groups（P0.05）.There was no significant difference of HBV DNA positive results in control group before and after treatment（P0.05）.There was significant difference of HBV DNA positive results in treated group before and after treatment（P0.05）.Conclusion Lamivudine combined xiaochahujiajiantang can reduce HBV DNA copy reproduction.