两种药物联合治疗老年晚期结直肠癌的临床研究

目的观察国产替吉奥胶囊（S-1）联合奥沙利铂（L-OHP）治疗老年晚期结直肠癌的近期疗效和不良反应。方法 29例老年晚期结直肠癌患者采用L-OHP（130mg/m2静脉滴注2h,d1）;S-1（40mg/m2,2次/天,1～14d）,21d为1个周期。至少完成2个周期后评价疗效及不良反应。结果 29例患者均可评价疗效,完全缓解（CR）1例,部分缓解（PR）13例,稳定（SD）12例,进展（PD）3例,有效率（CR＋PR）48.3%,疾病控制率（CR＋PR＋SD）89.7%。总生存时间（OS）为6～21个月,随访1年生存17例（58.6%）。主要不良反应为消化道反应、骨髓抑制、周围神经毒性等,无治疗相关性死亡。结论 S-1联合L-OHP治疗老年晚期结直肠癌的疗效好,不良反应较轻,值得临床推广。

The clinical study of combined treatment of two drugs for elderly patients with advanced colorectal cancer

Objective To evaluate the effect and adverse drug reaction of compound Tegafur capsule（S-1） plus oxaliplatin（L-OHP） for elderly patients with advanced colorectal cancer.Methods 29 elderly patients with advanced colorectal cancer were enrolled in this study.The chemotherapy regimen consisted of L-OHP（130 mg/m2,intravenous infusion for two hours,d1） and S-1（40 mg/m2,twice every day,1-14 d）,21 days a course,and the effect was assessed after no less than 2 cycles of treatment.Results All 29 patients were assessable for treatment effect and adverse drug reaction.Of 29 cases,there was CR in one case,PR in 13 cases,SD in 12 cases and PD in 3 cases,with all overall response rate（CR＋PR） was 48.3%,and the disease control rate（CR＋PR＋SD）was 89.7%;The overall survival time was 6-21 months,and one-year survival rate was 58.6%.The main adverse drug reaction were gastrointestina1 reactions,bone marrow depression and peripheral nerve toxicity.There was no treatment-related death.Conclusion The combined treatment of S-1 and L-OHP for elderly patients with advanced colorectal cancer has better efficacy and acceptable adverse drug reaction.This method is worthy to be promoted clinically.