麻疹疫苗联合 CHOP 方案治疗弥漫大 B 细胞淋巴瘤的临床研究

目的：探讨麻疹疫苗（measles vaccine）联合CHOP方案治疗弥漫大B细胞淋巴瘤（DLBCL）的临床疗效和毒副反应.方法：选择2006年1月至2011年12月住院治疗的DLBCL患者60例,随机分为观察组（30例）和对照组（30例）,观察组采用麻疹疫苗联合CHOP方案治疗,对照组采用单纯CHOP方案化疗.全部患者完成6个周期化疗.比较两组治疗效果,随访观察生存情况.结果：观察组总有效 （OR）率（CR＋PR）为83.3%（25/30）,对照组总有效（OR）率（CR＋PR）为60%（18/30）,比较差异有显著性（P＜0.05）.观察组和对照组1年PFS率为76.7%及50%（P＜0.05）,1年总生存率为90%及66.7%（P＜0.05）.结论：麻疹疫苗联合CHOP方案治疗弥漫大B细胞淋巴瘤有安全、有效、不良反应少、生存率高等优点,值得进一步研究.

Clinical study of measles vaccine combined with CHOP regimen in the treatment of diffuse large B cell lymphoma

Objective：To evaluate the efficacy and toxicity of combination chemotherapy consisting of lneasles vac- cine and CHOP for patients with diffuse large B - cell lylnpholna（DLBCL）. Methods：All 60 patients with DLBCL hospitalized froln January 2006 to Deeelnber 2011 were randomly assigned to receive either CHOP plus lneasles vac- cine （study group） or CHOP alone （ control group）. All of the patients have received 6 chemotherapy cycles. Results ： The overall respone （OR） rate was 83.3% （25/30） in the study group,and the OR rate was 60% （18/30） in the control group,with an obvious difference between the two groups （P 〈 0.05）. The 1 - year progression free survial were 76.7% and 50% in two groups （P 〈 0.05 ）. The 1 -year overall ssurvial rates were 90% and 66.7 % in two groups （ P 〈 0.05 ）. Conclusion ： Combination chemotherapy including measles vaccine and CHOP is effecitive and safe in treatment for DLBCL,fewer adverse reactions,and a higher survival rate.