| MAGE - 1 和 SCP - 1 在胃癌中的表达及相关性研究 |
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| 引用本文： | 杨安. MAGE - 1 和 SCP - 1 在胃癌中的表达及相关性研究[J]. 现代肿瘤医学, 2014, 0(3): 585-587 |
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| 作者姓名： | 杨安 |
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| 作者单位： | 邯郸市中心医院普外二科,河北邯郸056001 |
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| 基金项目： | 河北省科技厅支撑项目（编号：11276103D-31） |
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| 摘 要： | 目的：探讨肿瘤/睾丸抗原（cancer-testis antigen,CTA ）中MAGE-1、SCP-1在胃癌组织中表达情况及其意义.方法：采用微波EliVisionTM免疫组织化学法检测62例胃癌组织中MAGE-1、SCP-1的表达情况,并与42例正常胃黏膜组织（normal gastric mucose,NGM）进行比较.结果：胃癌组织中MAGE-1和SCP-1蛋白表达均定位于细胞浆,二者阳性率分别为70.97%（44/62）、32.26%（20/62）,在正常胃黏膜组织中不表达（P＜0.05）.MAGE-1、SCP-1的表达情况与有无淋巴结转移、胃癌的分化程度及病理分期有关 （P＜0.05）,相关性分析得出MAGE-1和SCP-1在胃癌组织中的表达情况存在一致性（P＜0.05）,二者之间表达呈正相关（P＜0.05）.结论：MAGE-1、SCP-1在胃癌中高表达,且在胃癌的发生、发展和转移过程中起到一定的作用.
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| 关 键 词： | 胃癌 MAGE-1 SCP-1 免疫组化 |
Expression and significance of MAGE-1 and SCP-1 in gastric carcinoma |
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| Yang An. Expression and significance of MAGE-1 and SCP-1 in gastric carcinoma[J]. Journal of Modern Oncology, 2014, 0(3): 585-587 |
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| Authors: | Yang An |
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| Affiliation: | Yang An (Hardan Central Hospital ,Hebei Handan 056001, China.) |
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| Abstract: | Objective：To determine the expression of MAGE - 1 and SCP - 1 in the gastric carcinoma and its sig- nificance. Methods：The MAGE - 1 and SCP - 1 were detected by microwave EliVisionTM and in 62 cases of gastric carcinoma and 42 cases of normal endometrial tissue. Results：The expression of MAGE - 1 and SCP - 1 was located in the plasma. The positive rates were 70.97% （44/62） ,32.26% （20/62） respectively which were higher than that in the normal tissue （P 〈 0.05）. MAGE - 1 and SCP - 1 were related with lymph node metastasis, differentiation de- gree and pathological staging（P 〈 0.05）. Conclusion： MAGE - 1 and SCP - 1 were highly expressed in the gastric carcinoma and their expressions were related with gastric carcinoma development and metastasis. |
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| Keywords: | gastric carcinoma MACE - 1 SCP - 1 immunohistochemistry |
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