肿瘤标志物联合检测在胸腹水性质鉴别中的临床应用

目的：探讨CEA、CA125、CYFRA21-1等8种肿瘤标志物检测在胸腹水鉴别诊断中的临床应用价值.方法：采用电化学发光法分别对176例患者的胸水和/或腹水进行癌胚抗原（CEA）、糖类癌抗原125 （CA125）、细胞角蛋白片段19（CYFRA21-1）等8项肿瘤标志物检测（其中恶性胸腹水81例,结核性胸腹水45例及不明原因胸腹水50例）,评价上述指标在鉴别胸腹水性质诊断中的灵敏度及特异性.结果：8项肿瘤标志物在良、恶性胸腹水中的表达水平具有显著性差异（P＜0.05）.恶性胸腹水中CEA、CA125、CYFRA21-1、NSE的水平及阳性率较高,分别为94%、81%、62%和52%.相关胸腹水肿瘤标志物联合检测对鉴别诊断不同良恶性胸腹水有统计学意义（P＜0.05）.结论：胸腹水中CEA、CA125、CYFRA21-1、NSE联合检测对良恶性胸腹水鉴别诊断有重要价值.

Clinical detection of tumor markers in differential diagnosis of pleural effusion and ascites

Objective： To investigate the clinical significance of 8 tumor markers, including CEA, CA125, CY-FRA21 - 1,in differential diagnosis of pleural effusion and ascites. Methods： Pleural effusion and ascites samplesfrom 176 patients,including 81 patients with malignant pleural effusion and ascites,45 patients with tuberculous pleu-ral effusion and ascites,50 patients with unexplained pleural effusion and ascites were collected. The level of eighttumor markers,including CEA, CA125, and CYFRA21 - 1, were detected with eleetroc hemistry luminescence meth-od. The sensitivity and specificity of these markers were evaluated. Results：The level of these eight tumor markers wassignificantly different between benign and maglinant pleural effusion and ascites. The level of CEA,CA125, CYFRA21- 1 and NSE was obviously higher in malignant pleural effusion and ascites,snd the positive rates were 94% ,81% ,62% and 52% respectively. Conclusion：The combination detection of CEA,CA125, CYFRA21 - 1 and NSE is of im-portant value in the differential diagnosis of pleural effusion and aseites.