Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats |
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| Authors: | Arun M Asha V V |
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| Affiliation: | Molecular Ethnopharmacology Lab, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India. |
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| Abstract: | Physalis peruviana is a medicinal herb used by Muthuvan tribes and Tamilian native who reside in the shola forest regions of Kerala, India against jaundice. It was evaluated for its antihepatotoxic, phytochemical analysis and the acute toxicity of the most promising extract in rats. Water, ethanol and hexane extracts of Physalis peruviana (500mg/kg body weight) showed antihepatotoxic activities against CCl(4) induced hepatotoxicity. The ethanol and hexane extracts showed moderate activity compared to water extract, which showed activity at a low dose of 125mg/kg. The results were judged from the serum marker enzymes. Histopathological changes induced by CCl(4) were also significantly reduced by the extract. Further, the extract administration to rats resulted in an increase in hepatic GSH and decrease in MDA. Preliminary phytochemical analysis revealed the presence of various components in the crude aqueous extract. The extract was found to be devoid of any conspicuous acute toxicity in rats. |
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| Keywords: | ALT, alanine aminotransferases AST, aspartate aminotransferases LDH, lactate dehydrogenase ANOVA, analysis of variants TBARS, thiobarbituric acid reactive substances CPCSEA, Committee for the Purpose of Control and Supervision of Experiments on Animals CCl4, carbon tetrachloride ALP, alkaline phosphate MDA, malondialdehyde GSH, reduced glutathione |
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