Chronic Myelocytic Leukemia: ORIGIN OF SOME LYMPHOCYTES FROM LEUKEMIC STEM CELLS |
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| Authors: | Philip J Fialkow A Michael Denman Robert J Jacobson and Mark N Lowenthal |
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| Institution: | Medical Genetics Section, Medical Service, Veterans Administration Hospital, Seattle, Washington, 98108 and Departments of Medicine and Genetics, University of Washington, Seattle, Washington 98195;Division of Immunological Medicine, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ, England;Baragwanath Hospital and Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa |
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| Abstract: | In three patients with chronic myelocytic leukemia who were heterozygous at the X-linked glucose-6-phospháte dehydrogenase locus, lymphocytes were studied to determine if they had the same stem cell origin as the leukemic myeloid cells. Normal tissues such as skin had both B and A glucose-6-phosphate dehydrogenase isoenzymes, but the leukemic myelogenous cells displayed only one isoenzyme type, consistent with their clonal origin. A population of cells with undoubted thymus-derived (T)-lymphocyte characteristics had both isoenzymes. Presumably, then, these T cells did not arise from the leukemic stem cell, either because they antedated the development of leukemia in that stem cell or, more likely, because they arose from progenitors not involved by the disease. In contrast, another population of lymphocytes showed only one isoenzyme type, suggesting that it arose from the chronic myelocytic leukemia stem cell. However, although this population contained many cells with the characteristics of bone marrow-derived (B) lymphocytes, it is not certain that the single enzyme produced by the cells over all can be attributed to B lymphocytes rather than to contaminating non-B-lymphoid cells. |
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