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| 磁共振动态增强扫描(DCE-MRI)检测易损性动脉粥样硬化斑块应用价值实验研究 | |
| 引用本文： | 曲晓峰,杨海山,刘书峰,刘亚洁,王乃玉. 磁共振动态增强扫描(DCE-MRI)检测易损性动脉粥样硬化斑块应用价值实验研究[J]. 中国实验诊断学, 2010, 14(2): 222-224 |
| 作者姓名： | 曲晓峰 杨海山 刘书峰 刘亚洁 王乃玉 |
| 作者单位： | 1. 吉林大学中日联谊医院,放射科,吉林,长春130033;大连医科大学附属二院,放射科 2. 吉林大学中日联谊医院,放射科,吉林,长春130033 3. 大连医科大学附属二院,放射科 4. 大连医科大学附属二院,病理科 |
| 摘 要： | 目的通过动物实验探讨磁共振动态增强扫描成像(Dynamic Contrast Enhanced MRI DCE-MRI)检测易损性动脉粥样硬化斑块临床应用价值。方法测定磁共振动态增强扫描动脉粥样硬化斑块首过时相斜率S及斑块峰值信号强度强化后120s信号强度下降率Soutflow,使用免疫组化方法标记动脉粥样硬化斑块内新生微血管内皮细胞与巨噬细胞。分析磁共振动态增强扫描参数与新生微血管内皮细胞计数(CD31免疫组化表达)和巨噬细胞计数(CD68免疫组化表达)相关性。结果磁共振动态增强扫描参数S和Soutflow与动脉粥样硬化斑块内新生微血管和巨噬细胞呈正相关(R=0.479,P0.01、R=0.452,P0.05R=0.415,P0.05、R=0.469,P0.01)。结论通过测定MR动态增强扫描参数评价动脉粥样硬化斑块内新生微血管量和炎症反应水平,MR动态增强扫描可以作为一项检测动脉粥样硬化斑块易损性影像学检查方法。 |
| 关 键 词： | 磁共振动态增强扫描 动脉粥样硬化斑块 易损性 |
Applying Value Experiment Study Of Dynamic Contrast Enhanced MR Iamging In Detecting Vulnerability Atherosclerotic Plaques of Rabbits |
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| QU Xiao-feng,YANG Hai-shan,LIU Shu-feng,et al.. Applying Value Experiment Study Of Dynamic Contrast Enhanced MR Iamging In Detecting Vulnerability Atherosclerotic Plaques of Rabbits[J]. Chinese Journal of Laboratory Diagnosis, 2010, 14(2): 222-224 | |
| Authors: | QU Xiao-feng YANG Hai-shan LIU Shu-feng et al. |
| Affiliation: | QU Xiao-feng,YANG Hai-shan,LIU Shu-feng,et al.(Radiology Department of China-japan Union Hospital Of Jilin University,Changchun 130033,China) |
| Abstract: | Objective To discuss applying value of dynamic contrast enhanced MR iamging in detecting vulnerability atherosclerotic plaques of rabbits Methods To evaluate the fist phase rate of slope (S) and the peak value signal last 120 s descent rate(Soutflow) and using immnohistochemical staining technique to observe endothelial cell in neovascularization(CD31) and macrophage(CD68)in atherosclerotic plaques.To discuss correlation of dynamic contrast enhanced MR imaging parameter and the count of neovascularization a... |
| Keywords: | Dynamic contrast enhanced MR imaging(DCE-MRI) atherosclerotic plaques vulnerability |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |