埃索美拉唑治疗反流性食管炎临床分析

目的 比较埃索美拉唑、贝络纳、达喜与法莫替丁、贝络纳、达喜治疗反流性食管炎近期疗效及半年复发情况。方法 将90例经内镜等检查诊断为反流性食管炎门诊患者随机分为治疗组和对照组，分别采用埃索美拉唑、贝络纳、达喜与法莫替丁、贝络纳、达喜治疗6周。结果 治疗组及对照组治疗6周后胸骨后疼痛，反酸，烧心及内镜下食管粘膜炎症恢复总有效率分别为88．9％，62．3％及91．1％，57．8％，半年复发率分别为13．3％及48．9％，二组比较有效率差异显著(P＜0．05)。结论 埃索美拉唑对反流性食管炎的近期及维持治疗均有良好疗效，无明显不良反应，但停药后复发率仍较高，需要维持治疗。

Clinical Analysis of Curative Effects of Esomeprazole on Reflux Esophagitis

Objective To compare the halfyear relapse and efficacy of Esomeprazoie with Famotidin in treat-ment of reflux esophagitis.Methods 90patients with reflux esophagitis diagnosised by endoscopy randomly di-vided into the observing group(Esomeprazole20mg once daily for6weeks)and the control group(Famotidin20mg twice daily for6weeks).All patient were reevaluted by endoscopy6weeks after treatment.Results The effective rate and endoscopic effiency rate and half year of relapse rate88.9%.91.1%,13.3%.for Famotidin group were62.3%.57.8%.48.9%.There was significant difference between observing group and control group with x 2 test the chinical curative rate corresponded with the endoscopy curative rate.Conclusions The safety and efficacy of Esomeprazole in treatment of reflux esophagitis.But recurrent rates was high after stopping treat-ment .Therefore,maintaining treament is required in many patients.