| 2-萘-3-(3,4-二甲氧基)苯丙烯酸抗血小板聚集作用及其机理 |
| |
| 引用本文： | 孙晓明,徐黻本. 2-萘-3-(3,4-二甲氧基)苯丙烯酸抗血小板聚集作用及其机理[J]. 中国药理学与毒理学杂志, 1988, 0(3) |
| |
| 作者姓名： | 孙晓明 徐黻本 |
| |
| 作者单位： | 中国药科大学药理教研室，中国药科大学药理教研室 南京 210009，南京 210009 |
| |
| 摘 要： | 研究发现,NMPA在体外可抑制花生四烯酸、胶原及凝血酶诱导的家兔血小板聚集,IC_(50)分别为189±9,105±11.0,49.8±16.6μM。小鼠ig NMPA(25mg/kg)后,以ADP诱导的血小板聚集明显受到抑制。大鼠ig NMPA后(52mg/kg一次或10mg/(kg·d)连续7d,出血时间延长、胶原诱导的血小板聚集率下降、丙二醛生成减少、但对动脉壁PGI_2样物质影响较小。说明MNPA的作用机理可能在于改变体内TXA_2/PGI_2比值,而达到抑制血小板聚集的效应。
|
| 关 键 词： | 2-萘-3-(3,4-二甲氧基)苯丙烯酸 血小板聚集 丙二醛 前列环素 |
Effect of 2-naphthyl-3-(3,4-dimethoxyl)phenylpropenoic acid on platelet aggregation and its mechanism |
| |
| SUN Xiao-ming,XU Fu-ben Dept of Pharmacology,China Pharmaceutical University,Nanjing. Effect of 2-naphthyl-3-(3,4-dimethoxyl)phenylpropenoic acid on platelet aggregation and its mechanism[J]. Chinese Journal of Pharmacology and Toxicology, 1988, 0(3) |
| |
| Authors: | SUN Xiao-ming XU Fu-ben Dept of Pharmacology China Pharmaceutical University Nanjing |
| |
| Affiliation: | SUN Xiao-ming,XU Fu-ben Dept of Pharmacology,China Pharmaceutical University,Nanjing,210009 |
| |
| Abstract: | Previous study showed that phenylpropenoic acid derivatives may inhibit platelet function. In this paper, the inhibitory effect of 2-naphthyl-3-(3,4) dimethoxyl)-phenylpropenoic acid (NMPA) on rabbit platelet aggregation has been revealed. The NMPA concentration of fifty percent inhibition (IC50) of platelet aggregation induced by arachidonic acid (AA), collagen or thrombin were 189 ?SD 9, 105 ?11 and .50?7 μM respectively. NMPA (25 mg/kg, ig) decreased the percentage of platelet aggregation induced by adenosine di phosphate (ADP)in mice.NMPA 25 mg/kgin a single dose or 10 mg/(kg·d) for 7 d, ig, prolonged the bleeding time, decreased the percentage of platelet aggregation induced by collQgen,and decreased the MDA forma tion, triggered by thrombin in rats. But the effect of NMPA on the formation of PGI2 like substance in rat artery, determined by bioactivity, was lesser than that of acetyl salicylic acid at same dosage. |
| |
| Keywords: | 2-naphthy 1-3-(3 4-dime thoxyl) phenylpropenoic acid platelet aggregation malondialdehyde prostacyclin |
| 本文献已被 CNKI 等数据库收录！ |
|
