Chordoma: an immunohistologic study |
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| Authors: | P Abenoza R K Sibley |
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| Affiliation: | 1. Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Guro, Seoul, South Korea;2. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Sungkyunkwan, South Korea;3. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Sungkyunkwan, South Korea;1. Tongji Medical Collage of Huazhong University of Science and Technology;2. Department of Neurosurgery, Tongji Medical School, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;1. Service de rhumatologie, centre hospitalier départemental site de La Roche-sur-Yon, Les Oudairies, 85925 La Roche-sur-Yon cedex 9, France;2. Service de pharmacie, centre hospitalier départemental site de La Roche-sur-Yon, Les Oudairies, 85925 La Roche-sur-Yon cedex 9, France;3. Service de rhumatologie, centre hospitalier du Mans, 194, avenue Rubillard, 72037 Le Mans, France;1. Department of Neurosurgery, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts, USA;2. Department of Pathology, Division of Neuropathology, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts, USA;3. Department of Neurology, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts, USA;4. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;5. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA;1. Department of Medical Oncology, Cancer Centre Henri Becquerel, Rouen, France;2. Department of Radiation Oncology and Medical Physics, Cancer Centre Henri Becquerel, Rouen, France;3. Department of Pathology, Rouen University Hospital, Rouen, France;4. IRON Group, UNIROUEN, Normandy Centre for Genomic and Personalized Medicine, Normandie University, Rouen, France;5. Department of Neurosurgery, Rouen University Hospital, Rouen, France;6. Department of Thoracic Surgery, Rouen University Hospital, Rouen, France;7. Department of Palliative Care, Rouen University Hospital, Rouen, France;8. Department of Radiology, Rouen University Hospital, Rouen, France |
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| Abstract: | Fourteen chordomas, five myxoid chondrosarcomas, and 15 chondroid tumors (four mesenchymal and 11 conventional chondrosarcomas) were stained for cytokeratin, S-100 protein, carcinoembryonic antigen (CEA), and vimentin. The epithelial markers stained 93 per cent of the chordomas, whereas none of the tumors of other types showed any staining. Sixty-four per cent of the chordomas, 20 per cent of the myxoid chondrosarcomas, and 87 per cent of the other chondroid tumors were positive for S-100 protein. All of the tumors were positive for vimentin. Three of the 14 chordomas were positive for CEA. The present study confirms the utility of these markers in the differential diagnosis of chordoma and tumors with similar histologic characteristics. |
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