复方苦参注射液对结直癌术后化疗患者免疫功能的影响

目的：探讨复方苦参注射液对结直癌术后化疗患者免疫功能的保护作用。方法：将80例结直癌术后患者随机分成2组。对照组给予FOLFOX4方案化疗;观察组所用化疗方案与对照组相同,同时加用复方苦参注射液20 mL·d-1治疗,共10 d。采用流式细胞仪测定治疗前后外周血T淋巴细胞亚群和NK细胞活性。结果：对照组化疗后外周血CD3^＋、CD4^＋、NK细胞数量及CD4^＋/CD8^＋细胞比值较化疗前显著下降（P＜0.05）,CD8＋细胞水平显著升高（P＜0.05）;观察组化疗后外周血CD3^＋、CD4^＋、CD8^＋、NK细胞数量及CD4＋/CD8＋细胞比值较化疗前无显著差异（P＞0.05）。化疗后观察组外周血CD3^＋、CD^4＋、NK细胞数量及CD4＋/CD8＋细胞比值均较对照组显著升高（P＜0.05）,CD8＋细胞水平与对照组无显著差异（P＞0.05）。结论：复方苦参注射液能较好地保护结直肠癌术后化疗患者的免疫功能。

Effects of Compound Kushen Injection on the Immunologic Function of Patients After Colorectal Cancer Resection

OBJECTIVE： To evaluate the effects of compound Kushen（Radix sophorae flavescentis） injection on the immunologic function of patients after colorectal cancer resection.METHODS： Eighty patients after colorectal cancer resection were randomly divided into two groups： 40 patients in control group were treated with routine chemotherapy including 5-fluorouridine（5-FU）,calcium folinate（CF） and oxaliplatin,40 patients in experimental group were treated with the same chemotherapy regime combined with 20 mL·d^-1 compound Kushen injection for lOd during chemotherapy. Flow cytometrywas used to examine the numbers of T lymphocytes subsets （CD3^＋ , CD4^＋ , CD4^＋/CD8^＋ ） and the NK cells in blood samples. RESULTS： In control group, the numbers of CD3^＋ , CD4^＋ T cells, NK cells and CD4^＋/CD8^＋ ratio significantly declined than those before chemotherapy （ P 〈 0.05 ） while CD8 ^＋ T lymphocyte number was increased significantly. In experimental group, there were no significant differences between the numbers of CD3^ ＋ , CD4^＋ , CD8 ^＋ T cells, NK cells, and CD4^＋/CD8^＋ ratio before and after chemotherapy（ P 〉 0.05）. After chemotherapy, the numbers of CD3^＋ , CD4^＋ T cells, NK cells and CD4^＋/CD8^＋ ratio were higher in experimental group than in control group（ P 〈 0.05）, while the number of CD8 ^＋ T lymphocyte was similar between two groups. CONCLUSION ： Compound Kushen injection can improve the immunologic function of patients receiving chemotherapy after colorectal cancer resection.