腮腺和颈部透明血管型Castleman病的临床分析

目的:分析探讨腮腺和颈部透明血管型Castleman病的临床表现、影像学检查、治疗方法及预后.方法:回顾性分析2004-2008年收治的10例腮腺和颈部透明血管型Castleman病患者的临床资料,包括性别、年龄、部位、病程、症状、体格检查、影像学检查、治疗方案、病理结果和随访结果.结果:10例患者中,男4例,女6例;就诊年龄13～54岁,平均26.6岁.病程3～48个月,平均12.5个月.肿块单发于腮腺3例,单发于颈部5例,多发于腮腺和颈部2例.所有患者术前均无明显不适症状,实验室检查无明显异常,影像学检查中CT和MRI/MRA有一定的鉴别诊断价值.所有患者均采用手术治疗,术后随访6～57个月,平均35.9个月,均无病变复发.结论:腮腺和颈部Castleman病的临床诊断较为困难,CT和MRI/MRA具有一定的鉴别诊断价值,治疗以手术为主,预后较好.

Clinical analysis of ten patients with Castleman disease hyaline vascular type in the parotid and neck region

PURPOSE： To analyze the clinical manifestation, image features, treatment and prognosis of Castleman disease hyaline vascular type in the parotid and neck region. METHODS： From 2004 to 2008, clinical data from ten patients with Castleman disease hyaline vascular type in the parotid and neck region were retrospectively reviewed, including sex, age, primary site, course of disease, symptom, physical examination, image examination, treatment protocol, pathological diagnosis, and follow-up result. RESULTS： Among the ten patients, there were four men and six females, their age ranged from 13 to 54 years with a mean age of 26.6 years. The course of disease ranged from 3 months to 4 years with a mean of 12.5 months. The primary lesions included the parotid region in 3 patients, neck in 5 patients, parotid and neck region in 2 patients. All patients had no obvious complaint and the laboratory examination was within the normal range. Computerized tomography and magnetic resonance imaging/angiography showed some clinical value for differential diagnosis. All patients received surgical operation, during the follow-up period from 6 to 57 months, mean 35.9 months, no recurrence of the lesion occurred. CONCLUSIONS： Castleman disease hyaline vascular type in the parotid and neck region is difficult to be diagnosed clinically, computerized tomography and magnetic resonance/angiography are somewhat useful for differential diagnosis. Surgical operation is the first-line treatment of choice for this disease with good prognosis.