应用UW-QOL评价口腔鳞癌患者的生存质量

目的:应用UW-QOL第4版评价口腔鳞癌患者的生存质量(quality of life,QOL).方法:采用直接翻译并经过适当修改的UW-QOL第4版,对97例确诊为口腔鳞癌的连续患者的术前QOL进行测量,术后3个月对其中55例患者的QOL作重复测量.采用SPSS12.0软件包分析量表的信度、效度和反应度.结果:量表总的克朗巴赫系数和分半信度分别为0.725和0.701;12个条目可提取4个因子,累计方差贡献率为65.4%;以SF-36中文版和FACT-H&N的头颈特异性子量表FACT-HN为效标,其效标效度分别为0.543和0.738;量表能敏感地区分已知的2组口腔癌患者术前QOL的差异及口腔癌患者QOL随时间的变化.结论:UW-QOL第4版具有良好的信度和反应度,其测定结构呈多维性,可用于中国人口腔癌患者生存质量的测量.

Evaluation quality of life in patients with oral squamous cell carcinoma using UW-QOL

PURPOSE： To evaluate the quality of life in patients with oral squamous cell carcinoma using UW-QOL version 4. METHODS： The quality of life（QOL） of 97 consecutive patients who were diagnosed as oral squamous cell carcinoma was assessed preoperatively with UW-QOL version 4 which was translated directly and modified necessarily. QOL of 55 patients was examined 3 months postoperatively. The validity, reliability and responsiveness of the scale were analyzed using SPSS12.0 software package. Statistical methods involved in this study included Mann-Whitney U test, Wilcoxon test, factor analysis, reliability analysis, and bivariate correlation analysis. RESULTS： The internal consistency of the instrument was 0.725, and the split-half reliability was 0.701. An exploratory factor analysis on the 12 items produced 4 factors, and the analysis explained 65.4% of the total variation. The eriterion validity with SF-36 and FACT-HN was 0.543 and 0.738, respectively. The instrument could detect the differences of preoperative QOL between T1＋T2 group and T3＋T4 group and the changes of QOL over time sensitively. CONCLUSION： The UW-QOL version 4 could measure the quality of life in oral cancer patients with good reliability, responsiveness and multi-dimensional constructs, it can be used in Chinese population with oral cancer.