谷胱甘肽对T3期直肠癌新辅助化疗患者的保护作用

目的：探讨T3期直肠癌患者新辅助化疗前后血谷胱甘肽（GSH）含量变化和应用外源GSH对减轻化疗药物不良反应及对机体的保护作用。方法：T3期直肠癌患者60例,随机分为GSH治疗组和对照组,每组30例。新辅助化疗采用氟脲嘧啶注射液、亚叶酸钙注射液静脉滴注。用分光光度计方法检测血浆GSH浓度。检测化疗前后肝肾功能。观察、记录患者恶心、呕吐和进食情况。结果：两组患者化疗前血浆GSH水平差异无显著性意义（P〉0.05）。化疗第2天,对照组患者血GSH水平下降,与化疗前相比,有显著性差异（P〈0.01）。GSH治疗组血浆新辅助化疗第2、5、7天血GSH水平显著高于对照组,两组差异有显著性意义（P〈0.01）。肝肾功能检查,两组术前血丙氨酸氨基转氨酶、胆红素、尿素氮、肌酐水平无显著性差异（P〉0.05）。化疗第5天,GSH组患者血丙氨酸氨基转氨酶、胆红素、尿素氮、肌酐水平低于对照组（P〈0.05）。新辅助化疗期间GSH组患者消化道反应症状较对照组患者轻。结论：GSH对T3期直肠癌新辅助化疗患者肝肾功能有保护作用,并减轻化疗不良反应,对保证患者新辅助化疗后手术安全有积极作用。

Glutathione Provides Protection for Patients with T3 Stage Rectal Cancer During Neoadjuvant Chemotherapy

OBJECTIVE：To study protedtive effect of glutathione（GSH）on patients of T3 stage rectal cancer during neoadjuvant chemotherapy.METHODS：60 cases of T3 rectal cancer were divided randomly into GSH group and control group,30 cases in each group.5-Fluoroufacil and Leukovorin were used for neoadjuvant chemotherapy,In GSH group,exogenous GSH was given during the chemotherapy.In the control group,only the chemotherapeutic agents were used.And plasma level of GSH was tested with spectrophotometry.Hepatic and renal functions were assayed.And patient＇s symptoms of nausea and vomiting were observed clinicly.RESULTS：The plasma levels of GSH between the two groups were no difference（P〉0.05）before neoadjuvant chemotherapy.At the second day of the chemotherapy,the GSH level decreased in the control group,and a significant difference（P〈0.01）was observed compared with before chemotherapy.But in GSH group,the GSH level increased at the 2th,the 5th and the 7th day.And the GSH level was also higher than that in the control group（P〈0.01）.Before the chemotherapy,hepatic and renal functions of the two groups was no differences（P〉0.05）.The plasma levels of glutamic-pyruvic transaminase,total bilirubin,uria nitrogen,and creatinine were increased in the control group and was higher than that in the GSH group（P〈0.05）at the 5th day after the chemotherapy.The clinical symtoms of nausea and vomiting in the GSH group modified significantly.CONCLUSION：GSH provides protective effects on hepatic and renal functions for patients of T3 stage rectal cancer,palliates adverse effects of chemotherapy agents,and is benefit to the safe operation following neoadjuvant chemotherapy.