埃索美拉唑在应用非甾体抗炎药患者中的预防作用

目的：观察埃索美拉唑对老年患者应用非甾体抗炎药引起消化性溃疡的预防作用。方法：选择不稳定性心绞痛和急性心肌梗死PCI术后服用非甾体类抗炎药的老年患者52例,随机分为对照组28例,埃索美拉唑组24例。对照组均服用阿司匹林每日100～300mg或加氯吡格雷每日75mg。埃索美拉唑组在应用阿司匹林治疗的基础上,口服埃索美拉唑每日40mg。4周后对患者上消化道症状及上消化道出血发生率进行比较。结果：对照组消化道出血发生率为10.7%,埃索美拉唑组未见消化道出血,两组比较差别显著（P〈0.05）。对照组出现上腹部不适症状发生率为17.8%,埃索美拉唑组出现上腹部不适为8.3%,两组比较差别无显著意义（P〉0.05）。结论：老年患者在应用非甾体抗炎药过程中预防性应用埃索美拉唑,能减轻消化道症状、预防消化道出血。

Preventive Effect of Esomeprazole on Non - steroidal Anti - inflammatory Drugs - induced Peptic Ulcer

OBJECTIVE：To observe the preventive effect of Esomeprazole on peptic ulcer induced by non-steroidal anti-inflammatory drugs（NSAIDs）in elderly patients.METHODS：Fifty-two elderly patients with unstable angina and acute myocardial infarction who were treated with NSAIDs after undergoing PCI surgery were randomly divided into control group（n=28）and Esomeprazole group（n=24）.The control group received aspirin 100～300 mg·d^-1 alone or in combination with clopidogrel（75 mg）qd;the treatment group received Esomeprazole（40 mg q.d）plus aspirin.After 4 weeks,the incidences of epigastric discomfort and the upper gastrointestinal bleeding were compared between the two groups.RESULTS：There were significant differences between the two groups in the incidence of upper gastrointestinal bleeding（10.7% for control group vs.none for Esomeprazole-treated group,P〈0.05）.However,there was no significant difference between the two group in the incidence of epigastric discomfort（17.8% for control group vs.8.3% for Esomeprazole-treated group,P〉0.05）.CONCLUSION：Preventive treatment with Esomeprazole for elderly patients receiving NSAIDs attenuates the upper gastrointestinal symptoms and prevents gastrointestinal bleeding.