| SCID小鼠-人白血病模型在白血病研究中的应用 |
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| 引用本文： | 聂小蒙,楼敬伟,王建民.SCID小鼠-人白血病模型在白血病研究中的应用[J].中国实验血液学杂志,2003,11(1):99-104. |
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| 作者姓名： | 聂小蒙 楼敬伟 王建民 |
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| 作者单位： | 第二军医大学附属长海医院血液科,上海,200433 |
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| 摘 要： | SCID小鼠-白血病模型是研究白血病细胞增殖、分化及其调控机制的重要手段和方法。本文综述了SCID小鼠-白血病模型的建立及研究进展，并对该模型在白血病发病学、白血病细胞生物、临床诊疗措施和判断病人预后等方面的可能应用进行了探讨。最后提出了此模型的应用局限性，以便更好地完善该模型，用于白血病的研究。
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| 关 键 词： | SCID小鼠－人白血病模型 NOD／SCID小鼠 白血病 |
| 文章编号： | 1009-2137(2003)01-0099-06 |
Application of SCID Mouse-Human Leukemia Model for Leukemia Research |
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| NIE Xiao Meng,LOU Jing Wei,WANG Jian Min.Application of SCID Mouse-Human Leukemia Model for Leukemia Research[J].Journal of Experimental Hematology,2003,11(1):99-104. |
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| Authors: | NIE Xiao Meng LOU Jing Wei WANG Jian Min |
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| Institution: | Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | SCID mouse human leukemia model is an important and useful tool for study on proliferation, differentiation and modulation of leukemic cells. In this article, the establishment of the model, advances in research and application in studies of pathogenesis, cell biology, clinical diagnosis, therapy and assessment of prognosis of leukemia patients are reviewed. The limitations of the model are also commented. |
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| Keywords: | SCID mouse human leukemia model NOD/SCID mouse leukemia |
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