| 不同时程慢性束缚水浸应激对大鼠胃窦Cajal间质细胞超微结构的影响 |
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| 引用本文： | 张丹,夏志伟,韩亚京. 不同时程慢性束缚水浸应激对大鼠胃窦Cajal间质细胞超微结构的影响[J]. 世界华人消化杂志, 2010, 18(6) |
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| 作者姓名： | 张丹 夏志伟 韩亚京 |
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| 作者单位： | 北京大学第三医院消化科,北京市,100191;北京大学第三医院消化科,北京市,100191;北京大学第三医院消化科,北京市,100191 |
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| 摘 要： | 目的:研究不同时程慢性束缚水浸应激大鼠胃窦Cajal间质细胞(ICC)的超微结构改变.方法:♂ SD大鼠48只随机分为6组、即实验3、7、28 d组和对照3、7、28 d组,每组8只.实验组每日束缚水浸1 h,对照组自由摄食饮水;于实验第4、8、29天晨禁食12 h后脱颈处死.取胃窦组织2块放入3%戊二醛中固定并电镜下观察ICC超微结构.结果:所有对照组ICC的超微结构均无异常改变,试验3、7、28 d各组ICC的超微结构与同期对照组比较均有明显的损害,主要表现为ICC的缝隙连接减少、细胞器减少等,以肌内ICC(ICC-MY)和肌间ICC(ICC-IM)为主:随着应激时间的延长,ICC的超微结构受损逐渐加重.结论:慢性束缚水浸应激可以损伤大鼠胃窦ICC的超微结构.
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| 关 键 词： | Cajal间质细胞 慢性束缚水浸应激 超微结构 |
Ultrastructural changes in interstitial cells of Cajal in the gastric antrum of rats undergoing water immersion-restraint stress |
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| Dan Zhang,Zhi-Wei Xia,Ya-Jing Han. Ultrastructural changes in interstitial cells of Cajal in the gastric antrum of rats undergoing water immersion-restraint stress[J]. World Chinese Journal of Digestology, 2010, 18(6) |
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| Authors: | Dan Zhang Zhi-Wei Xia Ya-Jing Han |
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| Affiliation: | Dan Zhang,Zhi-Wei Xia,Ya-Jing Han,Department of Di- gestive Diseases,Peking University Third Hospital,Beijing 100191,China |
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| Abstract: | AIM: To investigate the impact of chronic water immersion-restraint stress on the ultrastructure ofinterstitial cells of Cajal (ICC) in the gastric antrum of rats. METHODS: Forty-eight male Sprague-Dawley rats were randomly and equally divided into six groups: three experimental groups and three matched control groups. The three experimental groups underwent water immersion-restraint stress for one hour daily for 3, 7 and 14 days, re-spectively, while the three control groups were allowed free access to foo... |
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| Keywords: | Interstitial cells of Cajal Chronic water immersion-restraint stress Ultrastructure |
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