| 新型四环素类抗生素——amadacycline |
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| 引用本文： | 陈媛,王瑛瑛,陈宇瑛.新型四环素类抗生素——amadacycline[J].中国抗生素杂志,2012,37(4):301-307. |
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| 作者姓名： | 陈媛 王瑛瑛 陈宇瑛 |
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| 作者单位： | 中国医药集团总公司四川抗菌素工业研究所,成都,610052 |
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| 摘 要： | Amadacycline是新型抗菌氨基甲基四环素类药物,属于米诺环素的衍生物,具有广谱抗菌活性,抗菌谱与替加环素相似。体内外抗菌实验显示,amadacycline相对于其它抗生素,具有较强的广谱抗菌活性。前期临床实验显示:对复杂性皮肤和皮肤结构感染与利奈唑胺显示相似的疗效。另外,研究发现amadacycline与氨比西林、头孢噻肟、环丙沙星、克林霉素、庆大霉素、利福平、万古霉素没有药物间相互作用。Amadacycline具有良好的临床应用前景。
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| 关 键 词： | Amadacycline 氨基甲基四环素 广谱 复杂性皮肤和皮肤结构感染 |
Amadacycline,a new tetracycline antibiotics |
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| Chen Yuan
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Wang Ying-ying
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Chen Yu-ying.Amadacycline,a new tetracycline antibiotics[J].Chinese Journal of Antibiotics,2012,37(4):301-307. |
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| Authors: | Chen Yuan Wang Ying-ying Chen Yu-ying |
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| Institution: | (China National Pharmaceutical Group Corporation,Sichuan Industrial Institute of antibiotics, Department of Chemistry,Chengdu 610052) |
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| Abstract: | Amadacycline is a novel aminomethylcycline antibiotic with a broad spectrum of antibacterial activity,which is the similar as tigecycline.In clinical studies,amadacycline showed comparable efficacy to linezolid,and was no interaction between amadacycline and other antibiotics,including ampicillin,cefotaxime,ciprofloxacin,clindamycin,gentamicin,rifampicin,and vancomycin.Amadacycline has good clinical application prospect. |
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| Keywords: | Amadacycline Aminomethylcycline antibiotic Broad spectrum CSSI |
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