Benign mucous membrane pemphigoid with linear IgA deposits in oral mucosa |
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Authors: | JARKKO HIETANEN IMMO RANTALA TIMO REUNALA |
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Affiliation: | Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland;Department of Clinical Sciences, University of Tampere, Finland |
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Abstract: | Two patients with severe oral ulcerations and concomitant lesions in the nose, eyes and genitals were examined. The immunofluorescence (IFL) studies of buccal and genital mucosa revealed that the only deposited immunoglobulin was IgA. Immunoelectron microscopy confirmed the linear pattern of IgA deposition and localized IgA in lamina lucida in both patients. Dapsone 50 mg daily was effective in controlling the disease activity partially in the first and completely in the second patient. The results suggest that our patients had benign mucous membrane pemphigoid (BMMP) with linear IgA deposition but do not exclude a mucosal form of a newly recognized bullous skin disease termed linear IgA disease. |
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Keywords: | benign mucous membrane pemphigoid dapsone IgA deposits immunoclectron microscopy |
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