| 皮肤肿瘤中的雌激素受体及皮肤恶性黑素瘤中雌激素和孕激素受体及C－erbB2癌基因的表达 |
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| 引用本文： | 陈仁贵,唐曙,张文竹,凌波,余红,姜培红.皮肤肿瘤中的雌激素受体及皮肤恶性黑素瘤中雌激素和孕激素受体及C－erbB2癌基因的表达[J].临床皮肤科杂志,1996(3). |
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| 作者姓名： | 陈仁贵 唐曙 张文竹 凌波 余红 姜培红 |
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| 作者单位： | Department of Dermatology，Xin Hua Hospital，Shanghai Second Medical University |
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| 摘 要： | 通过对８个病种的２１例皮肤恶性肿瘤进行的雌激素受体的免疫组化标记（ＡＢＣ法），发现有２例皮肤恶性黑素瘤呈阳性表达。在１５例皮肤恶性黑素瘤中进行的免疫组化染色中（ＬＳＡＢ），雌激素受体阳性７例、孕激素受体阳性３例、Ｃ－ｅｒｂＢ２癌基因阳性７例。作者认为通过进一步研究有望获得恶性黑素瘤激素治疗和预后观察的生物学依据
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| 关 键 词： | 恶性肿瘤，皮肤黑素瘤，皮肤受体，雌激素受体，孕激素癌基因 |
Expression of estrogen receptor in cutaneous malignant tumor and estrogen receptor,progesterone receptor and C-erbB_2 oncoprotein in cutaneous malignant melanoma |
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| Chen Rengui,Tang Shu, Zhang Wenzhu, et al.Expression of estrogen receptor in cutaneous malignant tumor and estrogen receptor,progesterone receptor and C-erbB_2 oncoprotein in cutaneous malignant melanoma[J].Journal of Clinical Dermatology,1996(3). |
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| Authors: | Chen Rengui Tang Shu Zhang Wenzhu |
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| Abstract: | The skin biopsy specimens of 21 patients with cutaneous malignant tumor were immunohistochemically stained with the estrogen receptor, two cases of cutaneous malignant melanoma showed positive result. In addition, of fifteen patients with cutaneous malignant melanoma, seven were positive to estrogen receptor, three to progesterone receptor and seven to C-erbB_2 oncoprotein. The authors consider that it will be hopeful to get biologic evidences for the steroid treatments and improving the prognosis of cutaneous malignant melanoma by further investigation. |
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| Keywords: | Cutaneous malignant tumor Malignant melanoma Receptor estrogen Receptor progesterone Oncoprotein C-erbB_2 |
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