| 筋膜间室综合征治疗的实验研究 |
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| 引用本文： | 王志刚,张伯勋,刘郑生,王兵. 筋膜间室综合征治疗的实验研究[J]. 解放军医学杂志, 2001, 26(8): 598-600 |
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| 作者姓名： | 王志刚 张伯勋 刘郑生 王兵 |
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| 作者单位： | 解放军总医院 |
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| 摘 要： | 应用袖带压迫法建立新的筋膜间室综合征动物模型,观察用药前后血CPK、MDA、组织压以及病理学变化,研究甘露醇和山莨菪碱对筋膜间室综合征的治疗作用.结果发现,治疗组血清酶含量及组织压较对照组下降(P＜0.01);神经、肌肉组织变性程度减轻、范围缩小.说明本法建立的模型是成功的;甘露醇对筋膜间室综合征有明确的治疗作用,并可防治缺血再灌注损伤;山莨菪碱对改善微循环、减轻肢体肿胀有确切疗效;血CPK可做为判断筋膜间室综合征疗效的指标.
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| 关 键 词： | 筋膜间室综合征 甘露醇 山莨菪碱 自由基 再灌注损伤 |
| 修稿时间： | 2000-12-28 |
AN EXPERIMENTAL STUDY ON THE TREATMENT OF COMPARTMENT SYNDROME |
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| Wang Zhigang,Zhang Boxun,Liu Zhengsheng et al. AN EXPERIMENTAL STUDY ON THE TREATMENT OF COMPARTMENT SYNDROME[J]. Medical Journal of Chinese People's Liberation Army, 2001, 26(8): 598-600 |
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| Authors: | Wang Zhigang Zhang Boxun Liu Zhengsheng et al |
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| Affiliation: | Wang Zhigang,Zhang Boxun,Liu Zhengsheng et al . General Hospital of PLA,Beijing 100853 |
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| Abstract: | In order to determine the efficacy of mannitol and anisodamine in the treatment of compartment syndrome, a new animal model of compartment syndrome was used to observe the changes in CPK, MDA, tissue pressure and pathology before and after the use of the drugs. The results showed that the values of CPK, MDA and intracompartmental pressure declined and pathological changes improved after the therapy. The result indicated that this new animal model is reproducible and successful. Mannitol is useful in the treatment of compartment syndrome, and at the same time it acts as a free radical scavenger, so that it can prevent reperfusion injury. Anisodamine can improve the limb's microcirculation. CPK can be an index for judging the therapeatic effect in the treatnent of compartment syndrome. |
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| Keywords: | compartment syndrome mannitol Anisodamine free radicals reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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