CGMS分析那格列奈与阿卡波糖治疗老年人2型糖尿病疗效比较

目的:采用动态血糖监测技术(CGMS)动态比较那格列奈与阿卡波糖治疗老年人2型糖尿病患者的临床疗效.方法:将60例(大于或等于60岁)单纯饮食加运动疗法治疗不满意的2型糖尿病患者随机分为那格列奈组(n=31)及阿卡波糖组(n=29),疗程为4周.测定并比较两组患者治疗前后动态血糖监测数据,糖化血红蛋白(HbA1C),空...

Comparative Study on the Therapeutic Efficacy of Nateglinide Versus Acarbose in Treatment of Type 2 Diabetic Patients in the Elderly by Continues Glucose Monitoring System

Objective： To compare the clinical therapeutic efficacy of the nateglinide and acarbose ontype 2 diabetic patients in the elderly by continues glucose monitoring system（GMS）.Method： Sixty pa-tients with type 2 diabetes mellitus in the elderly aged over 60 years,were randomly divided into two groupsand treated for 4 weeks either with nateglinide（n = 31） or acarbose（n =29）,respectively.The valuesof CGMS,HbA1C,FINS,P2hINS,blood-fat and BMI were periodically measured and compared beforeand after treatment.Result： The concentrations of FPG decreased both in nateglinide group and acarbosegroup respectively（P 0.01）.Nateglinide could reduce the value of P2hBG significantly（P 0.01）.The levels of HbA1C were significantly decreased in two groups,but there＇s no statistically significant differ-ence（P 0.05）.The values of P2hINS were significantly increased（P 0.01） as compared withthose in nateglinide group before treatment,but were significantly decreased（P 0.01） in acarbose groupafter treatment.Conclusion： It shows that treatment with nateglinide could decrease levels of the averageblood glucose and postprandial blood glucose more significantly（P 0.05） than the treatment with acar-bose,while the decrease of 3： 00 am blood glucose was less（P 0.05） in the former than in the latter,asa result making the daily blood glucose excursion more smoother.Acabose has the effect of reducing post-prandial insulin secretion,regulating blood-fat,thus is more suitable to obese type 2 diabetics.