洛铂联合替加氟治疗晚期食管癌的临床观察

目的观察洛铂联合替加氟方案治疗晚期食管癌的近期疗效和不良反应。方法观察组26例采用洛铂+替加氟方案：洛铂 30 mg/m2，静脉滴注，d1,替加氟500 mg/m2,静脉滴注，d1～d5，21天为1周期。对照组22例采用顺铂+氟尿嘧啶方案：顺铂 20 mg/m2，静脉滴注，d1～d4,氟尿嘧啶500 mg/m2,静脉滴注，d1～d5，21天为1周期。2周期后评价疗效。结果48例患者均可评价疗效。观察组有效率为53.8%，对照组为50.0%，两组患者近期疗效差异无统计学意义（P＞0.05），但两组间消化道反应及血小板减少差异均有统计学意义（P＜0.05）。结论洛铂联合替加氟治疗晚期食管癌疗效较好，不良反应可耐受，使用安全。

Short-term Effect of Lobaplatin Plus Futraful Chemotherapy on Treatment of Advanced Esophageal Carcinoma

ObjectiveTo observe the recent efficacy and toxicity of lobaplatin plus futraful chemotherapy in the treatment of advanced esophageal carcinoma.MethodsTwenty-six patients in the observing group were treated with lobaplatin plus futraful regimen: lobaplatin 30 mg/m2 ivdrip d1 and futraful 500 mg/m2 ivdrip d1～5; while the other 22 patients in the control group were treated with cisplatin plus 5-Fu regimen: cisplatin 20 mg/m2 ivdrip d1～4 and 5-Fu 500 mg/m2 ivdrip d1～ d5.21 days were as a cycle.The efficacy was evaluated after two cycles.ResultsThe efficacy and toxicity could be assessed in all the 48 patients.The response rate of the observing and control group were 53.8% (14/26) and 50.0% (11/22),respectively.There was no significant difference between the two groups in the recent efficacy（P＞0.05）.However，gastrointestinal reactions and thrombocytopenia showed significant difference（P＜0.05）.ConclusionLobaplatin plus futraful regimen is safe and effective in the treatment of advanced esophageal carcinoma.