CD83 is a regulator of murine B cell function in vivo |
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Authors: | Breloer Minka Kretschmer Birte Lüthje Katja Ehrlich Svenja Ritter Uwe Bickert Thomas Steeg Christiane Fillatreau Simon Hoehlig Kai Lampropoulou Vassiliki Fleischer Bernhard |
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Affiliation: | Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany. MBreloer@aol.com |
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Abstract: | The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation of B cell function. CD83 is up-regulated on activated B cells in vivo, specifically in the draining lymph nodes of Leishmania major-infected mice. The ubiquitous transgenic (Tg) expression of CD83 interferes with Leishmania-specific T cell-dependent and with T cell-independent antibody production. This defect is restricted to the B cell population since the antigen-specific T cell response of CD83Tg mice to L. major infection is unchanged. The defective immunoglobulin (Ig) response is due to Tg expression of CD83 on the B cells because wild-type B cells display normal antigen-specific responses in CD83Tg hosts and CD83Tg B cells do not respond to immunization in a mixed wild-type/CD83Tg bone marrow chimera. Finally, the treatment of non-Tg C57BL/6 mice with anti-CD83 mAb induces a dramatic increase in the antigen-specific IgG response to immunization, thus demonstrating a regulatory role for naturally induced CD83 on wild-type B cells. |
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Keywords: | Antibody response B cell activation Transgenic mice |
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