Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis |
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| Institution: | 1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea;2. KU-KIST School, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea;3. School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea;4. School of Chemical Engineering, Sungkyunkwan University, Suwan 440-746, Republic of Korea.;5. School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.;1. CEB — Centre of Biological Engineering, University of Minho, Campus of Gualtar, Braga, Portugal;2. CBMA — Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus of Gualtar, Braga, Portugal |
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| Abstract: | We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA. |
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| Keywords: | Au/Fe/Au plasmonic nanoparticles Magnetic targeting Chemo-photothermal treatment Rheumatoid arthritis |
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