Bioreducible heparin-based nanogel drug delivery system |
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| Affiliation: | 2. Department of Fashion Design, Canakkale Applied Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, Canakkale, Turkey;3. Department of Physics and Engineering Physics, Tulane University, New Orleans, LA, United States;1. The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China;2. Key Laboratory of Textile Science & Technology of Ministry of Education, Donghua University, Shanghai, China;3. Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai, China |
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| Abstract: | Bioreducible heparin (HEP)-based nanogels were prepared by derivatizing HEP with vinyl group followed by copolymerizing with cystamine bisacrylamide in aqueous medium in the absence of surfactant. The hydrodynamic diameter of the HEP nanogels could be tuned in the range from 80 to 200 nm. Doxorubicin (DOX) was loaded into the HEP nanogels, and high drug loading content (30%) and efficiency (90%) were achieved. In vitro drug release test revealed that this drug delivery system exhibited strongly redox-sensitive drug release behavior that would greatly favor the in vivo drug delivery performance of the nanogels. After injected into tumor-bearing mice through tail vein, the DOX-loaded HEP nanogels showed remarkable accumulation in tumors as demonstrated by in vivo near infared fluorescence imaging and ex vivo DOX concentration measurements. The doxorubicin accumulation at tumor site goes beyond 9% injected dose per gram of tumor through such delivery system, making that DOX-loaded HEP nanogels have significantly superior in vivo antitumor activity. |
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| Keywords: | Heparin Nanogel Doxorubicin Antitumor |
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