Fucoidan But Not 2′-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae |
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| Authors: | Malcolm Turk Hsern Tan Yan Li Mohamad Eshaghi Gorji Zhiyuan Gong Dan Li |
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| Affiliation: | 1.Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore 119077, Singapore; (M.T.H.T.); (M.E.G.);2.Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 119077, Singapore; (Y.L.); (Z.G.) |
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| Abstract: | Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2′-Fucosyllactose (2′-FL). As a result, although both fucoidan and 2′-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2′-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect. |
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| Keywords: | norovirus, fucoidan, 2′ -fucosyllactose, antiviral |
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