Fabrication and characterization of medical grade polyurethane composite catheters for near-infrared imaging |
| |
| Affiliation: | 1. Engineering Faculty, Department of Chemistry, İstanbul University-Cerrahpasa, İstanbul, Turkey;2. Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, İstanbul University-Cerrahpasa, İstanbul, Turkey;3. Faculty of Veterinary Medicine, Department of Histology and Embryology, İstanbul University-Cerrahpasa, İstanbul, Turkey;1. Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego Street 6, 44-100 Gliwice, Poland;2. Center of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej Street 34, 41-819 Zabrze, Poland;3. Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza Street 30, 30-059 Krakow, Poland;4. Faculty of Chemistry, Jagiellonian University, Ingardena Street 3, 30-060 Krakow, Poland;5. Department of Microbiology, Jagiellonian University Medical College, Czysta 18 Street, 31-121 Krakow, Poland;1. Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, MI 48109-1055, USA;2. Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331-4003, USA;3. Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA;4. Department of Surgery, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-5686, USA |
| |
| Abstract: | Peripherally inserted central catheters (PICCs) are hollow polymeric tubes that transport nutrients, blood and medications to neonates. To determine proper PICC placement, frequent X-ray imaging of neonates is performed. Because X-rays pose severe health risks to neonates, safer alternatives are needed. We hypothesize that near infrared (NIR) polymer composites can be fabricated into catheters by incorporating a fluorescent dye (IRDye 800CW) and visualized using NIR imaging. To fabricate catheters, polymer and dye are dry mixed and pressed, sectioned, and extruded to produce hollow tubes. We analyzed surface roughness, stiffness, dye retention, NIR contrast intensity, and biocompatibility. The extrusion process did not significantly alter the mechanical properties of the polymer composites. Over a period of 23 days, only 6.35 ± 5.08% dye leached out of catheters. The addition of 0.025 wt% dye resulted in a 14-fold contrast enhancement producing clear PICC images at 1 cm under a tissue equivalent. The addition of IRDye 800CW did not alter the biocompatibility of the polymer and did not increase adhesion of cells to the surface. We successfully demonstrated that catheters can be imaged without the use of harmful radiation and still maintain the same properties as the unaltered medical grade equivalent. |
| |
| Keywords: | Catheter Cell adhesion Polyurethane Fluorescence Mechanical testing |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
