Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy? |
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| Institution: | 1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China;2. Laboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China;3. Beijing National Laboratory of Molecular Sciences, Key Laboratory of Organic Solid, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, PR China;4. Department of Chemistry, University of Zurich, Winterthurer-strasse 190, CH-8057 Zurich, Switzerland;1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China;2. School of Material Science and Engineering, University of Jinan, 250022, Jinan, PR China;3. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, PR China;1. Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bio-Inspired Energy Materials and Devices, School of Chemistry and Environment, Beijing University of Aeronautics and Astronautics, Beijing 100191, PR China;2. China Academy of Machinery of Science & Technology, Beijing 100044, PR China;3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Chinese Academy of Sciences, Shanghai 200050, PR China;1. Departament de Farmacologia, Toxicologia i Química Terapèutica and Institut de Nanociència i Nanotecnologia UB (IN2UB), Universitat de Barcelona, Avda. Joan XXIII 27-31, 08028 Barcelona, Spain;2. School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK;1. Department of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur- 603 203, Kancheepuram (DT), Tamil Nadu, India;2. Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602 105, Tamil Nadu, India |
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| Abstract: | The design and development of functional hybrid nanomaterials is currently a topic of great interest in biomedicine. Herein we investigated the grafting of Ru(II) polypyridyl complexes onto gold nanospheres (Ru@AuNPs) to improve the particles' near infrared (NIR) absorption, and ultimately allow for application in photothermal cancer therapy. As demonstrated in this article, these ruthenium(II) complexes could indeed significantly enhance gold nanospheres' two-photon luminescence (PTL) intensity and photothermal therapy (PTT) efficiency. The best dual functional nanoparticles of this study were successfully used for real-time luminescent imaging-guided PTT in live cancer cells. Furthermore, in vivo tumor ablation was achieved with excellent treatment ef?cacy under a diode laser (808 nm) irradiation at the power density of 0.8 W/cm2 for 5 min. This study demonstrates that the coupling of inert Ru(II) polypyridyl complexes to gold nanospheres allows for the enhancement of two-photon luminescence and for efficient photothermal effect. |
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| Keywords: | Photothermal Two-photon luminescence Ru(II) complex Gold nanospheres |
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