A statistical assessment of clinical equivalence |
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| Authors: | J Mau |
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| Affiliation: | Institute of Medical Biometry, University of Tubingen, F.R.G. |
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| Abstract: | An observed confidence distribution is proposed as a measure of strength of evidence for practically equivalent efficacies of two treatments. The concept is independent of prior opinions about relevant sizes of a difference in efficacy. It also avoids retrospective power calculations for trials with missed recruitment goals and allows combination of the confidence from independent experiments. |
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| Keywords: | Clinical equivalence Confidence intervals Strength of evidence |
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