A monoclonal antibody with reaction spectrum covering acute leukemia and T-lineage cells |
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| Authors: | E Nogiwa K Tamaki M Omine T Maekawa |
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| Affiliation: | Third Department of Internal Medicine, Gunma University School of Medicine, Japan. |
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| Abstract: | A mouse monoclonal antibody (MA-10) was raised using cells of a patient with AML (M2). MA-10 reacted with leukemic cells in 44 out of 60 AML cases. Intense reaction was observed especially in 32/38 cases with M1 and M2, as well as 9/9 with common ALL and 2/2 with T-ALL. No appreciable reaction was observed with mature blood cells with only exception of T cells. In-vitro addition of MA-10 did not affect the growth of GM-CFC and BFU-e from two patients with CML in chronic phase. MA-10 identified three polypeptides of approximate mol. wt of 74,000, 50,000 and 30,000. |
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